To change a saved search into an email alert, change the option under Alert Frequency from "None" to another value and save the changes.
To cancel an alert, either set the option under Alert Frequency to "None" or delete the associated saved search
From the American Psychiatric Association
It is almost imposible to keep current with what is happening in the health care professions. Pubmed alone adds the citations to over half a million articles each year. These pages are designed to aid you in setting up processes that can help you keep up with what is published in your field.
Three ways to keep up with the literature
1. Journals: Set up Table of Contents (TOC) email alerts for the different Journals in your field
Most publishers will require that you set up a user account if you don't already have one.
2. Databases: Set up save searches for your research topics that can be run on a regular basis
Ex.-Saved searches in PubMed using My NCBI: Click here to register
3. Books: Creating Preferred Searches on the broad subjects you are interested in.